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Tuesday, July 28, 2020 | History

4 edition of Colonic drug absorption and metabolism found in the catalog.

Colonic drug absorption and metabolism

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Published by M. Dekker in New York .
Written in English

    Subjects:
  • Colon (Anatomy) -- Effect of drugs on.,
  • Drugs -- Metabolism.,
  • Colon -- drug effects.,
  • Colon -- metabolism.,
  • Drugs -- metabolism.

  • Edition Notes

    Includes bibliographical references and index.

    Statementedited by Peter R. Bieck.
    SeriesDrugs and the pharmaceutical sciences ;, v. 60
    ContributionsBieck, Peter R., 1938-
    Classifications
    LC ClassificationsRM355 .C65 1993
    The Physical Object
    Paginationviii, 224 p. :
    Number of Pages224
    ID Numbers
    Open LibraryOL1408685M
    ISBN 100824790138
    LC Control Number93017265

    Title:Absorption, Disposition, and Pharmacokinetics of Saponins from Chinese Medicinal Herbs: What Do We Know and What Do We Need to Know More? VOLUME: 13 ISSUE: 5 Author(s):Ke Yu, Feng Chen and Chuan Li Affiliation:Laboratory for DMPK Research of Herbal Medicines, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Haike Road, Zhangjiang Hi-Tech Park, Shanghai Cited by:   Gut Microbes & Drug Metabolism. Drugs also need to be metabolized and detoxified. Nearly a century ago, research groups discovered that gut microbes play a role in drug metabolism. Today, more than 50 drugs have been shown to be metabolized by gut bacteria (36, 37). Indeed, the “first pass effect,” or the extent to which a drug is.

    Butyric acid (from Ancient Greek: βούτῡρον, meaning "butter"), also known under the systematic name butanoic acid is a carboxylic acid with the structural formula CH 3 CH 2 CH 2 CO 2 H. Classified as a carboxylic acid, it is an oily, colorless liquid that is soluble in water, ethanol, and ether. Isobutyric acid (2-methylpropanoic acid) is an isomer. Chemical formula: C, ₃H, ₇COOH. Colonic absorption of MCFAs is a contributing factor to oral MCT therapy in small bowel compromised patients. Relevance to course [ edit ] The article is relevant to the course Biochemistry: Metabolism because the article discusses the ability of the large intestine to absorb small chain fatty acids as well as medium chain fatty acids in the.

      20 A) Drug pKa and GI pH: Amount of drug that exists in un-ionized form and in ionized form is a function of pKa of drug and pH of the fluid at the absorption site, and it can be determined by Handerson-Hasselbach equation: For weak acids, pH = pKa + log [ionized] [un-ionized]..() % Drug ionized = 10 pH-pKa x .   form of the drug: While considering the salt form of drug, ph of the diffusion layer on important not the ph of the bulk of the solution. Example of salt of weak acid: It increases the ph of the diffusion layer, which promotes the solubility the dissolution of a weak acid and absorption is bound to be rapid. Other approach to enhance.


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Colonic drug absorption and metabolism Download PDF EPUB FB2

ISBN: OCLC Number: Description: viii, pages: illustrations ; 24 cm. Contents: Anatomical and physiological basis: physiological factors influencing drug absorption / Christine A. Edwards --Drug metabolism in the colon wall and lumen / Johann W.

Faigle --In vitro studies with colonic tissue, cellular, and subcellular preparations / Pierre Dechelotte and. The colonic absorption of drugs can differ significantly from absorption in the small intestine as a consequence of several physiological, physicochemical, and biopharmaceutical factors.

The permeability through passive transport is thought to be lower in colonic than in other intestinal tissue because of the smaller surface area and tighter. Colonic Drug Absorption and Metabolism (Drugs and the Pharmaceutical Sciences) [Bieck, Peter] on *FREE* shipping on qualifying offers.

Colonic Drug Absorption and Metabolism (Drugs and the Pharmaceutical Sciences). The details on scientific background and factors that influence F h are outside the scope of this book chapter; interested readers are encouraged to refer to our recent reviews in these areas (Thomas et al.Hurst et al.

Varma et al. ) and other chapters in this book that focus on metabolism and related topics such as induction and inhibition of drug metabolism, pharmacogenetics Cited by: EXPERT OPINION: Colonic drug absorption is one of the critical considerations in successful development of oral ER products.

The root causes of low colonic absorption in many LCA drugs are still unclear. It is recommended to evaluate colonic drug absorption of drug candidate at early stage of oral ER product by: 1. Download Colonic Drug Absorption and Metabolism (Drugs and the Pharmaceutical Sciences) Ebook.

Colonic Drug Absorption and Metabolism, edited by Peter R. Bieck Pharmaceutical Particulate Carriers: Therapeutic Applications, edited by Alain Rolland Drug Permeation Enhancement: Theory and Applications, edited by Dean S. Hsieh Glycopeptide Antibiotics, edited by. The solubilization of drug is the rate-limiting factor in colonic drug absorption due to low colonic luminal fluid volume, higher viscosity, and neutral pH.

Further, nonspecific interactions of the drug with the colonic content, for example, dietary residues, intestinal secretions, mucus, or fecal matter can have a negative influence on the.

The absorption rate coefficients and the permeability values of atenolol were determined in the colon (n = ) in the absence and presence of counter ions by using in situ "closed loop" perfusion Author: Hiroaki Yuasa.

F7: The role of keratins in colon energy metabolism. The SCFA butyrate is the primary source of energy for colonic epithelium and is involved in the maintenance of epithelial homeostasis.

Butyrate and other SCFAs are produced by the colonic microflora via fermentation of, for example, dietary fiber. Colonic drug delivery has gained increased importance not just for the delivery of the drugs for the treatment of local diseases associated with the colon like Crohn's disease, ulcerative colitis.

Drug interactions can occur at the site of action (pharmacodynamic interactions), and during the absorption, ­distribution, metabolism and excretion Cited by: 8. The most important site for GIT drug absorption is the small intestine due to the large absorptive surface area as a result of the presence of villi and microvilli Drug absorption is generally believed to be higher in the upper region of the small intestine compared with the lower parts due to higher permeability 3.

Oesophageal absorption Cited by: The collective genome of the human intestinal microbiota is comprised of million genes, approximately times more genes than are in the human genome [].The metabolome, or the metabolic signature of an individual, is dependent not only upon the host but also upon the interaction of the host with the microflora [2,3,5,6].Some of the metabolites found in a host are exclusively the result Cited by: This material is available free of charge via the Internet at http: Supporting Information is available free of charge on the ACS Publications website at DOI: /7b Table S1, HPLC-HRMS-based identifications of SREMs, 5C-RFMs, phenyl-γ-valerolactones, and phenyl-γ-hydroxyvaleric acids in human urine collected 0–30 h after theaflavin consumption and after.

The colon specific drug delivery system should have capability to protect the drug en route to the colon i.e. drug release and drug absorption should not occur in the stomach as well as the small intestine, and the bioactive agent should not be degraded in either of the dissolution sites but only released and absorbed once the system reaches.

A number of the colonic catabolites originating from gallic acid and theaflavins has been reported to be bioactive in ex vivo and in vitro models with a variety of potential modes of action. Bioavailability of Black Tea Theaflavins: Absorption, Metabolism, and Colonic Catabolism - Journal of Agricultural and Food Chemistry (ACS Publications)Cited by: The vast majority of intestinal K+ absorption occurs in the small intestine; the contribution of the normal colon to net K+ absorption and secretion is trivial.

K+ is absorbed or secreted mainly by passive mechanisms; the rectum and perhaps the sigmoid colon have the capacity to actively secrete K+, but the quantitative and physiological Cited by: Physiological factors influencing oral drug absorption.

The gastrointestinal tract is complex. Figure outlines some of the main structures involved in and key physiological parameters that affect oral drug absorption. In order to gain an insight into the numerous factors that can potentially influence the rate and extent of drug absorption into the systemic circulation, a schematic.

Prodrugs are chemistry-enabled drug delivery modifications of active molecules designed to enhance their pharmacokinetic, pharmacodynamic and/or biopharmaceutical properties.

Ideally, prodrugs are efficiently converted in vivo, through chemical or enzymatic transformations, to the active parent molecule. The goal of this work is to enhance the colonic absorption of a drug molecule with a short Cited by: 8.

Download PDF: Sorry, we are unable to provide the full text but you may find it at the following location(s): g (external link)Author: D S Rampton.Colonic Drug Absorption and Metabolism, edited by Peter Pharmaceutical Particulate Carriers: Therapeutic Applications, edited by Alain Rolland Drug Permeation Enhancement: Theory and Applications, edited by Dean Glycopeptide Antibiotics, edited by.

Production and absorption of SCFAs. Total and relative molar concentrations of the main SCFAs, acetate, propionate and butyrate produced in the human intestine, depend on the site of fermentation, diet and composition of the intestinal microbiota.

7 Absolute concentrations of butyrate in human faeces were found to range from 11 to 25 m m, 8, 9 and molar ratios of acetate to propionate Cited by: